MYCN Gene Copy Number Status Detected by FISH Method and Its Correlation with Outcome and Clinicopathological Variables in Childhood Neuroblastoma

MYCN Gene Copy Number Status Detected by FISH Method and Its Correlation with Outcome and Clinicopathological Variables in Childhood Neuroblastoma

Background: Neuroblastoma is the most common extracranial solid tumor in children. MYCN gene amplification (MNA) is an independent prognostic factor for rapid tumor progression and poor prognosis, regardless of age and clinical stage. Gain of the MYCN gene locus on the short arm of chromosome 2 can...

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Bibliographic Details
Main Authors: Mahdi Shahriari, Akbar Safaei, Parvaneh Davoudi, Bozorgmehr Hedayati
Format: Article
Language:English
Published: Shiraz University of Medical Sciences 2024-01-01
Series:Middle East Journal of Cancer
Subjects:
neuroblastoma
mycn amplification
chemotherapy
refractory
progression-free survival
Online Access:https://mejc.sums.ac.ir/article_49334_dc31e55e123b9b1ca84e030605b3a92a.pdf

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https://mejc.sums.ac.ir/article_49334_dc31e55e123b9b1ca84e030605b3a92a.pdf

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