Prophylaxis and treatment of Alzheimer's disease by delivery of an adeno-associated virus encoding a monoclonal antibody targeting the amyloid Beta protein.

Prophylaxis and treatment of Alzheimer's disease by delivery of an adeno-associated virus encoding a monoclonal antibody targeting the amyloid Beta protein.

We previously reported on a monoclonal antibody (mAb) that targeted amyloid beta (Aß) protein. Repeated injection of that mAb reduced the accumulation of Aß protein in the brain of human Aß transgenic mice (Tg2576). In the present study, cDNA encoding the heavy and light chains of this mAb were subc...

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Bibliographic Details
Main Authors: Masaru Shimada, Shinya Abe, Toru Takahashi, Kazumasa Shiozaki, Mitsue Okuda, Hiroaki Mizukami, Dennis M Klinman, Keiya Ozawa, Kenji Okuda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3610755?pdf=render

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http://europepmc.org/articles/PMC3610755?pdf=render

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