Simvastatin Embedded into Poly(Lactic-Co-Glycolic Acid)-Based Scaffolds in Promoting Preclinical Bone Regeneration: A Systematic Review

Simvastatin Embedded into Poly(Lactic-Co-Glycolic Acid)-Based Scaffolds in Promoting Preclinical Bone Regeneration: A Systematic Review

Simvastatin embedded into poly(lactic-co-glycolic acid) (PLGA)-based scaffolds can stimulate bone regeneration in preclinical models. However, the ideal pharmacological dose has not been evaluated. This systematic review reports on the simvastatin doses used in preclinical studies and evaluates the...

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Bibliographic Details
Main Authors: Eduarda Blasi Magini, Luiza de Oliveira Matos, Raissa Borges Curtarelli, Mariane Beatriz Sordi, Gabriel Leonardo Magrin, Carlos Flores-Mir, Reinhard Gruber, Ariadne Cristiane Cabral Cruz
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Applied Sciences
Subjects:
drug delivery systems
simvastatin
bone regeneration
polylactic acid-polyglycolic acid copolymer
systematic review
Online Access:https://www.mdpi.com/2076-3417/12/22/11623

Internet

https://www.mdpi.com/2076-3417/12/22/11623

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