Naphtho[1,8-<i>de</i>][1,2]Oxazin-4-ol: Precursor to 1,2,8-Trisubstituted Naphthalenes and 1-Unsubstituted Naphtho[1,2-<i>d</i>]isoxazole 2-Oxide: A Novel Isomerization of the <i>N</i>-Oxide to Nitrile Oxide <i>en Route</i> to Isoxazol(in)es

Naphtho[1,8-<i>de</i>][1,2]Oxazin-4-ol: Precursor to 1,2,8-Trisubstituted Naphthalenes and 1-Unsubstituted Naphtho[1,2-<i>d</i>]isoxazole 2-Oxide: A Novel Isomerization of the <i>N</i>-Oxide to Nitrile Oxide <i>en Route</i> to Isoxazol(in)es

Naphtho[1,8-<i>de</i>][1,2]oxazin-4-ol and its acyl or benzyl derivatives ring open to various 2,8-dihydroxy-1-naphthonitriles, which, through (de)protection protocols and reduction, afford the target (<i>E</i>)-2-hydroxy-8-methoxy-1-naphthaldehyde. This was converted to its...

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Bibliographic Details
Main Authors: Ioannis E. Gerontitis, Petros G. Tsoungas, George Varvounis
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Molecules
Subjects:
naphthols
oxime
oxidation
isomerization
nitrile oxide
1,3-dipolar cycloaddition
Online Access:https://www.mdpi.com/1420-3049/29/1/48

Internet

https://www.mdpi.com/1420-3049/29/1/48

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