Defective hematopoietic differentiation of immune aplastic anemia patient-derived iPSCs

Defective hematopoietic differentiation of immune aplastic anemia patient-derived iPSCs

Abstract In acquired immune aplastic anemia (AA), pathogenic cytotoxic Th1 cells are activated and expanded, driving an immune response against the hematopoietic stem and progenitor cells (HSPCs) that provokes cell depletion and causes bone marrow failure. However, additional HSPC defects may contri...

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Bibliographic Details
Main Authors: Maria Florencia Tellechea, Flávia S. Donaires, Vinícius S. de Carvalho, Bárbara A. Santana, Fernanda B. da Silva, Raissa S. Tristão, Lílian F. Moreira, Aline F. de Souza, Yordanka M. Armenteros, Lygia V. Pereira, Rodrigo T. Calado
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04850-5

Internet

https://doi.org/10.1038/s41419-022-04850-5

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