Detection limit of 89Zr-labeled T cells for cellular tracking: an in vitro imaging approach using clinical PET/CT and PET/MRI

Detection limit of 89Zr-labeled T cells for cellular tracking: an in vitro imaging approach using clinical PET/CT and PET/MRI

Abstract Purpose Tracking cells in vivo using imaging can provide non-invasive information to understand the pharmacology, efficacy, and safety of novel cell therapies. Zirconium-89 (t 1/2 = 78.4 h) has recently been used to synthesize [89Zr]Zr(oxinate)4 for cell tracking using positron emission tom...

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Bibliographic Details
Main Authors: Laura M. Lechermann, Roido Manavaki, Bala Attili, Doreen Lau, Lorna B. Jarvis, Tim D. Fryer, Nick Bird, Luigi Aloj, Neel Patel, Bristi Basu, Matthew Cleveland, Franklin I. Aigbirhio, Joanne L. Jones, Ferdia A. Gallagher
Format: Article
Language:English
Published: SpringerOpen 2020-07-01
Series:EJNMMI Research
Subjects:
PET
Cell labeling
Cell tracking
Zirconium-89
Detection limit
Online Access:http://link.springer.com/article/10.1186/s13550-020-00667-5

Internet

http://link.springer.com/article/10.1186/s13550-020-00667-5

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