Chrysophanol inhibits of colorectal cancer cell motility and energy metabolism by targeting the KITENIN/ErbB4 oncogenic complex

Chrysophanol inhibits of colorectal cancer cell motility and energy metabolism by targeting the KITENIN/ErbB4 oncogenic complex

Abstract Background Expression of the KITENIN/ErbB4 oncogenic complex is associated with metastasis of colorectal cancer to distant organs and lymph nodes and is linked with poor prognosis and poor survival. Methods Here, we used in vitro and in silico methods to test the ability of chrysophanol, a...

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Bibliographic Details
Main Authors: Mücahit Varlı, Eunae Kim, Songjin Oh, Sultan Pulat, Rui Zhou, Chathurika D. B. Gamage, Barış Gökalsın, Nüzhet Cenk Sesal, Kyung Keun Kim, Man-Jeong Paik, Hangun Kim
Format: Article
Language:English
Published: BMC 2024-07-01
Series:Cancer Cell International
Subjects:
Chrysophanol
Anthraquinone
KITENIN
ErbB4
Metastasis
Aerobic glycolysis
Online Access:https://doi.org/10.1186/s12935-024-03434-x

Internet

https://doi.org/10.1186/s12935-024-03434-x

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