Fanca−/− hematopoietic stem cells demonstrate a mobilization defect which can be overcome by administration of the Rac inhibitor NSC23766
Fanconi anemia is a severe bone marrow failure syndrome resulting from inactivating mutations of Fanconi anemia pathway genes. Gene and cell therapy trials using hematopoietic stem cells and progenitors have been hampered by poor mobilization of HSC to peripheral blood in response to G-CSF. Using a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ferrata Storti Foundation
2009-07-01
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| Series: | Haematologica |
| Online Access: | https://haematologica.org/article/view/5287 |