Icariin regulates miR-23a-3p-mediated osteogenic differentiation of BMSCs via BMP-2/Smad5/Runx2 and WNT/β-catenin pathways in osteonecrosis of the femoral head

Icariin regulates miR-23a-3p-mediated osteogenic differentiation of BMSCs via BMP-2/Smad5/Runx2 and WNT/β-catenin pathways in osteonecrosis of the femoral head

Icariin is commonly used for the clinical treatment of osteonecrosis of the femoral head (ONFH). miR-23a-3p plays a vital role in regulating the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). The present study aimed to investigate the roles of icariin and miR-23a-3...

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Bibliographic Details
Main Authors: Xiao-yun Zhang, Hua-nan Li, Feng Chen, Yue-ping Chen, Yuan Chai, Jian-zhao Liao, Bin Gan, Ding-peng Chen, Song Li, Yong-qian Liu
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Saudi Pharmaceutical Journal
Subjects:
Icariin
miR-23a-3p
Osteonecrosis of the femoral head
BMP-2/Smad5/Runx2 pathway
WNT/β-catenin pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016421002115

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http://www.sciencedirect.com/science/article/pii/S1319016421002115

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