Activation-induced deaminase in B lymphocyte maturation and beyond

Activation-induced deaminase in B lymphocyte maturation and beyond

Activation-induced deaminase (AID), a member of the AID/apolipoprotein B mRNA-editing enzyme-catalytic (APOBEC) family, deaminates DNA cytidines into uridines and is the major trans-acting player of immunoglobulin (Ig) genes' diversification in mature B lymphocytes. It allows multiple antigen-d...

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Bibliographic Details
Main Author: Michel Cogné
Format: Article
Language:English
Published: Elsevier 2013-12-01
Series:Biomedical Journal
Subjects:
Activation-induced deaminase
class-switching
hypermutation
locus suicide
lymphomagenesis
Online Access:http://www.biomedj.org/article.asp?issn=2319-4170;year=2013;volume=36;issue=6;spage=259;epage=268;aulast=Cogn%E9

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http://www.biomedj.org/article.asp?issn=2319-4170;year=2013;volume=36;issue=6;spage=259;epage=268;aulast=Cogn%E9

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