hiPSC-derived neural stem cells from patients with schizophrenia induce an impaired angiogenesis

Abstract Schizophrenia is a neurodevelopmental disease characterized by cerebral connectivity impairment and loss of gray matter. It was described in adult schizophrenia patients (SZP) that concentration of VEGFA, a master angiogenic factor, is decreased. Recent evidence suggests cerebral hypoperfus...

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Bibliographic Details
Main Authors: Bárbara S. Casas, Gabriela Vitória, Marcelo N. do Costa, Rodrigo Madeiro da Costa, Pablo Trindade, Renata Maciel, Nelson Navarrete, Stevens K. Rehen, Verónica Palma
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-018-0095-9