Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation.

Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation.

Targeted mutations in mouse disrupt local chromatin structure and may lead to unanticipated local effects. We evaluated targeted gene promoter silencing in a group of six mutants carrying the tm1a Knockout Mouse Project allele containing both a LacZ reporter gene driven by the native promoter and a...

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Bibliographic Details
Main Authors: Julia V Kirov, Michael Adkisson, A J Nava, Andreana Cipollone, Brandon Willis, Eric K Engelhard, K C Kent Lloyd, Pieter de Jong, David B West
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4537176?pdf=render

Internet

http://europepmc.org/articles/PMC4537176?pdf=render

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