Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition

Blockade of endothelial adenosine receptor 2 A suppresses atherosclerosis in vivo through inhibiting CREB-ALK5-mediated endothelial to mesenchymal transition

Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and morbidity and mortality rates continue to rise. Atherosclerosis constitutes the principal etiology of CVDs. Endothelial injury, inflammation, and dysfunction are the initiating factors of atherosclerosis. Recently, we repor...

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Bibliographic Details
Main Authors: Yongfeng Cai, Yaqi Zhou, Qiuhua Yang, Jiean Xu, Qingen Da, Qian Ma, Dingwei Zhao, Tammy Lu, Ha Won Kim, David Fulton, Xuejun Jiang, Neal L. Weintraub, Kunzhe Dong, Suowen Xu, Mei Hong, Zhiping Liu, Yuqing Huo
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Pharmacological Research
Subjects:
Adenosine receptor 2 A
Endothelial to mesenchymal transition
Atherosclerosis
ALK5
CREB
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824001002

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http://www.sciencedirect.com/science/article/pii/S1043661824001002

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