New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens—a PARC project

New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens—a PARC project

Carcinogenic chemicals, or their metabolites, can be classified as genotoxic or non-genotoxic carcinogens (NGTxCs). Genotoxic compounds induce DNA damage, which can be detected by an established in vitro and in vivo battery of genotoxicity assays. For NGTxCs, DNA is not the primary target, and the p...

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Main Authors: Marc Audebert, Ann-Sophie Assmann, Amaya Azqueta, Pavel Babica, Emilio Benfenati, Sylvie Bortoli, Peter Bouwman, Albert Braeuning, Tanja Burgdorf, Xavier Coumoul, Kloé Debizet, Maria Dusinska, Norman Ertych, Jörg Fahrer, Verena Fetz, Ludovic Le Hégarat, Adela López de Cerain, Harm J. Heusinkveld, Kevin Hogeveen, Miriam N. Jacobs, Mirjam Luijten, Giuseppa Raitano, Cynthia Recoules, Elise Rundén-Pran, Mariam Saleh, Iva Sovadinová, Martina Stampar, Lea Thibol, Céline Tomkiewicz, Ariane Vettorazzi, Bob Van de Water, Naouale El Yamani, Bojana Zegura, Michael Oelgeschläger
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Toxicology
Subjects:
non-genotoxic carcinogens
NGTxC
new approach methodologies
NAM
PARC
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2023.1220998/full

Internet

https://www.frontiersin.org/articles/10.3389/ftox.2023.1220998/full

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