Kinetics of Water-Induced Amorphous Phase Separation in Amorphous Solid Dispersions via Raman Mapping

Kinetics of Water-Induced Amorphous Phase Separation in Amorphous Solid Dispersions via Raman Mapping

The poor bioavailability of an active pharmaceutical ingredient (API) can be enhanced by dissolving it in a polymeric matrix. This formulation strategy is commonly known as amorphous solid dispersion (ASD). API crystallization and/or amorphous phase separation can be detrimental to the bioavailabili...

Full description

Bibliographic Details
Main Authors: Adrian Krummnow, Andreas Danzer, Kristin Voges, Samuel O. Kyeremateng, Matthias Degenhardt, Gabriele Sadowski
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Pharmaceutics
Subjects:
phase behavior
miscibility gap
amorphous phase separation
kinetics
Raman imaging
confocal Raman spectroscopy
Online Access:https://www.mdpi.com/1999-4923/15/5/1395

Internet

https://www.mdpi.com/1999-4923/15/5/1395

Similar Items