Pro-Inflammatory Cytokines and Antibodies Induce hnRNP A1 Dysfunction in Mouse Primary Cortical Neurons

Pro-Inflammatory Cytokines and Antibodies Induce hnRNP A1 Dysfunction in Mouse Primary Cortical Neurons

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system with a significant neurodegenerative component. Dysfunctional RNA-binding proteins (RBPs) are causally linked to neuronal damage and are a feature of MS, including the mislocalization of the RBP heterogeneous nuclear ri...

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Bibliographic Details
Main Authors: Muxue Li, Rachel Hamilton, Hannah E. Salapa, Michael C. Levin
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Brain Sciences
Subjects:
RNA-binding protein
multiple sclerosis
stress granules
heterogeneous nuclear ribonucleoprotein A1
cytokines
autoimmunity
Online Access:https://www.mdpi.com/2076-3425/11/10/1282

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https://www.mdpi.com/2076-3425/11/10/1282

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