Dynamics of a model for the degradation mechanism of aggregated α-synuclein in Parkinson's disease
Accumulation of the misfolded synaptic protein α-synuclein (αSyn*) is a hallmark of neurodegenerative disease in Parkinson's disease (PD). Recent studies suggest that the autophagy lysosome pathway (ALP) including both the Beclin1-associated and mTOR-signaling pathways is involved in the αSyn*...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-04-01
|
Series: | Frontiers in Computational Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fncom.2023.1068150/full |