Prophylactic Evidence of MSCs-Derived Exosomes in Doxorubicin/Trastuzumab-Induced Cardiotoxicity: Beyond Mechanistic Target of NRG-1/Erb Signaling Pathway

Prophylactic Evidence of MSCs-Derived Exosomes in Doxorubicin/Trastuzumab-Induced Cardiotoxicity: Beyond Mechanistic Target of NRG-1/Erb Signaling Pathway

Trastuzumab (Trz) is a humanized monoclonal antibody targeting epidermal growth factor receptor 2 (HER2; ErbB2). The combined administration of Trz and doxorubicin (DOX) has shown potent anti-cancer efficacy; however, this regimen may be accompanied by severe cardiac toxicity. Mesenchymal stem cells...

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Bibliographic Details
Main Authors: Nesrine Ebrahim, Hajir A. Al Saihati, Ola Mostafa, Amira Hassouna, Sameh Abdulsamea, Eman Abd El Aziz M. El Gebaly, Nashwa Hassan Abo-Rayah, Dina Sabry, Mohamed El-Sherbiny, Abdelmonem G. Madboly, Noha Ibrahim Hussien, Raja El Hasnaoui Saadani, Hasnaa Ali Ebrahim, Omnia A. M. Badr, Nehal M. Elsherbiny, Rabab F. Salim
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
trastuzumab
doxorubicin
stem cells
exosomes
cardiac toxicity
NRG-1
Online Access:https://www.mdpi.com/1422-0067/23/11/5967

Internet

https://www.mdpi.com/1422-0067/23/11/5967

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