Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
Cancer: A search for safer signaling targets More effective treatments for cancer could be developed by targeting signaling pathway regulators that are expressed solely in cancer cells. Disruption to a major signaling pathway known as Wnt, which is involved in processes including cell proliferation,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-02-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-020-0380-6 |
| _version_ | 1818392908079824896 |
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| author | Youn-Sang Jung Jae-Il Park |
| author_facet | Youn-Sang Jung Jae-Il Park |
| author_sort | Youn-Sang Jung |
| collection | DOAJ |
| description | Cancer: A search for safer signaling targets More effective treatments for cancer could be developed by targeting signaling pathway regulators that are expressed solely in cancer cells. Disruption to a major signaling pathway known as Wnt, which is involved in processes including cell proliferation, tissue homeostasis and tissue regeneration, is now recognized as a significant contributor to the development of certain cancers. Jae-Il Park and Youn-Sang Jung at the University of Texas MD Anderson Cancer Center, Houston, USA, reviewed recent research into Wnt signaling in cancer and possible therapies. Scientists have developed Wnt inhibitors for cancer treatment, but these have detrimental side effects including skeletal degeneration and abdominal pain. New studies suggest there are Wnt signaling regulators that are specifically expressed in cancer cells, which may prove to be more effective drug targets than blocking Wnt signaling as a whole. |
| first_indexed | 2024-12-14T05:36:53Z |
| format | Article |
| id | doaj.art-bb77a696695b4d39b07898608c7fce6f |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-14T05:36:53Z |
| publishDate | 2020-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-bb77a696695b4d39b07898608c7fce6f2022-12-21T23:15:08ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132020-02-0152218319110.1038/s12276-020-0380-6Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complexYoun-Sang Jung0Jae-Il Park1Department of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Experimental Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer CenterCancer: A search for safer signaling targets More effective treatments for cancer could be developed by targeting signaling pathway regulators that are expressed solely in cancer cells. Disruption to a major signaling pathway known as Wnt, which is involved in processes including cell proliferation, tissue homeostasis and tissue regeneration, is now recognized as a significant contributor to the development of certain cancers. Jae-Il Park and Youn-Sang Jung at the University of Texas MD Anderson Cancer Center, Houston, USA, reviewed recent research into Wnt signaling in cancer and possible therapies. Scientists have developed Wnt inhibitors for cancer treatment, but these have detrimental side effects including skeletal degeneration and abdominal pain. New studies suggest there are Wnt signaling regulators that are specifically expressed in cancer cells, which may prove to be more effective drug targets than blocking Wnt signaling as a whole.https://doi.org/10.1038/s12276-020-0380-6 |
| spellingShingle | Youn-Sang Jung Jae-Il Park Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex Experimental and Molecular Medicine |
| title | Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex |
| title_full | Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex |
| title_fullStr | Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex |
| title_full_unstemmed | Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex |
| title_short | Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex |
| title_sort | wnt signaling in cancer therapeutic targeting of wnt signaling beyond β catenin and the destruction complex |
| url | https://doi.org/10.1038/s12276-020-0380-6 |
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