SGK1-regulated metabolism: key for the survival of cells detached from the extracellular matrix
Cells that lack attachment to the extracellular matrix (ECM) experience metabolic defects that can lead to caspase-independent cell death. Recently, we discovered that serum and glucocorticoid kinase-1 (SGK1) plays a critical role in the regulation of glucose metabolism, the promotion of energy prod...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-09-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2021.1976583 |
| _version_ | 1797677102930067456 |
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| author | Jordan A. Cockfield Zachary T. Schafer |
| author_facet | Jordan A. Cockfield Zachary T. Schafer |
| author_sort | Jordan A. Cockfield |
| collection | DOAJ |
| description | Cells that lack attachment to the extracellular matrix (ECM) experience metabolic defects that can lead to caspase-independent cell death. Recently, we discovered that serum and glucocorticoid kinase-1 (SGK1) plays a critical role in the regulation of glucose metabolism, the promotion of energy production, and ultimately the survival of ECM-detached cells. Abbreviations: ECM, extracellular matrix; SGK1, serum and glucocorticoid kinase-1; ROS, reactive oxygen species; CCCP, cyanide m-chlorophenyl hydrazine; PPP, pentose phosphate pathway; G3P, glyceraldhyde-3-phosphate; shRNA, short hairpin RNA; TCA, tricarboxylic acid |
| first_indexed | 2024-03-11T22:40:10Z |
| format | Article |
| id | doaj.art-bb78f2c9d506411a88e326cb6e61f62d |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:10Z |
| publishDate | 2021-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-bb78f2c9d506411a88e326cb6e61f62d2023-09-22T09:19:43ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562021-09-018510.1080/23723556.2021.19765831976583SGK1-regulated metabolism: key for the survival of cells detached from the extracellular matrixJordan A. Cockfield0Zachary T. Schafer1University of Notre DameUniversity of Notre DameCells that lack attachment to the extracellular matrix (ECM) experience metabolic defects that can lead to caspase-independent cell death. Recently, we discovered that serum and glucocorticoid kinase-1 (SGK1) plays a critical role in the regulation of glucose metabolism, the promotion of energy production, and ultimately the survival of ECM-detached cells. Abbreviations: ECM, extracellular matrix; SGK1, serum and glucocorticoid kinase-1; ROS, reactive oxygen species; CCCP, cyanide m-chlorophenyl hydrazine; PPP, pentose phosphate pathway; G3P, glyceraldhyde-3-phosphate; shRNA, short hairpin RNA; TCA, tricarboxylic acidhttp://dx.doi.org/10.1080/23723556.2021.1976583sgk1ecm-detachmentanoikisglucose metabolismpentose phosphate pathwaysignal transduction |
| spellingShingle | Jordan A. Cockfield Zachary T. Schafer SGK1-regulated metabolism: key for the survival of cells detached from the extracellular matrix Molecular & Cellular Oncology sgk1 ecm-detachment anoikis glucose metabolism pentose phosphate pathway signal transduction |
| title | SGK1-regulated metabolism: key for the survival of cells detached from the extracellular matrix |
| title_full | SGK1-regulated metabolism: key for the survival of cells detached from the extracellular matrix |
| title_fullStr | SGK1-regulated metabolism: key for the survival of cells detached from the extracellular matrix |
| title_full_unstemmed | SGK1-regulated metabolism: key for the survival of cells detached from the extracellular matrix |
| title_short | SGK1-regulated metabolism: key for the survival of cells detached from the extracellular matrix |
| title_sort | sgk1 regulated metabolism key for the survival of cells detached from the extracellular matrix |
| topic | sgk1 ecm-detachment anoikis glucose metabolism pentose phosphate pathway signal transduction |
| url | http://dx.doi.org/10.1080/23723556.2021.1976583 |
| work_keys_str_mv | AT jordanacockfield sgk1regulatedmetabolismkeyforthesurvivalofcellsdetachedfromtheextracellularmatrix AT zacharytschafer sgk1regulatedmetabolismkeyforthesurvivalofcellsdetachedfromtheextracellularmatrix |