Allosteric Interactions between Adenosine A<sub>2A</sub> and Dopamine D<sub>2</sub> Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and Opportunities for PET Imaging

Allosteric Interactions between Adenosine A<sub>2A</sub> and Dopamine D<sub>2</sub> Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and Opportunities for PET Imaging

Adenosine and dopamine interact antagonistically in living mammals. These interactions are mediated via adenosine A<sub>2A</sub> and dopamine D<sub>2</sub> receptors (R). Stimulation of A<sub>2A</sub>R inhibits and blockade of A<sub>2A</sub>R enhances...

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Bibliographic Details
Main Authors: Kavya Prasad, Erik F. J. de Vries, Philip H. Elsinga, Rudi A. J. O. Dierckx, Aren van Waarde
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
adenosine A<sub>2A</sub> receptor
dopamine D<sub>2</sub> receptor
heteromers
allosteric interaction
receptor–receptor interactions
striatum
Online Access:https://www.mdpi.com/1422-0067/22/4/1719

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https://www.mdpi.com/1422-0067/22/4/1719

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