Sickle cell cerebrovascular reactivity to a CO2 stimulus: Too little, too slow

Sickle cell cerebrovascular reactivity to a CO2 stimulus: Too little, too slow

Background: Despite increased cerebral blood flow (CBF), cerebral infarcts occur in patients with sickle cell disease (SCD). This suggests increased CBF does not meet metabolic demand possibly due to compromised cerebral vasodilatory response. Hypothesis: In adult SCD patients, cerebrovascular react...

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Bibliographic Details
Main Authors: Stéphanie Forté, Olivia Sobczyk, Julien Poublanc, James Duffin, Gregory M. T. Hare, Joseph Arnold Fisher, David Mikulis, Kevin H. M. Kuo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Physiology
Subjects:
sickle cell disease (SCD)
cerebrovascular reactivity (CVR)
cerebrovascular reactivity to carbon dioxide
functional magnetic resonance imaging (fMRI)
cerebral hemodynamics
cerebral blood flow (CBF)
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.886807/full

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https://www.frontiersin.org/articles/10.3389/fphys.2022.886807/full

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