The E484K Substitution in a SARS-CoV-2 Spike Protein Subunit Vaccine Resulted in Limited Cross-Reactive Neutralizing Antibody Responses in Mice

The E484K Substitution in a SARS-CoV-2 Spike Protein Subunit Vaccine Resulted in Limited Cross-Reactive Neutralizing Antibody Responses in Mice

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), especially emerging variants, poses an increased threat to global public health. The significant reduction in neutralization activity against the variants such as B.1.351 in the serum of convalescent patients and vaccinated people calls f...

Full description

Bibliographic Details
Main Authors: Longbo Hu, Yuhua Xu, Liping Wu, Jin Feng, Lu Zhang, Yongjie Tang, Xiang Zhao, Runming Mai, Liyun Chen, Lingling Mei, Yuanzhen Tan, Yingying Du, Yanping Zhen, Wenhan Su, Tao Peng
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Viruses
Subjects:
SARS-CoV-2
B.1.351
E484K
subunit vaccine
neutralizing antibody
Online Access:https://www.mdpi.com/1999-4915/14/5/854

Internet

https://www.mdpi.com/1999-4915/14/5/854

Similar Items