Sevoflurane up-regulates miR-7a to protect against ischemic brain injury in rats by down-regulating ATG7 and reducing neuronal autophagy

Sevoflurane up-regulates miR-7a to protect against ischemic brain injury in rats by down-regulating ATG7 and reducing neuronal autophagy

The current study aimed to elucidate the effects of Sevoflurane on neuronal autophagy and ischemic brain injury by regulating miR-7a/ATG7 axis. The rat model of middle cerebral artery occlusion (MCAO) was established by thread embolization. The expression pattern of microRNA-7a (miR-7a) and autophag...

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Bibliographic Details
Main Authors: Zhiguo Wu, Jian Tan, Lichang Lin, Wenting Zhang, Wanqiu Yuan
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Brain Research Bulletin
Subjects:
Ischemic brain injury
Sevoflurane
MicroRNA-7a
ATG7
MCAO rat model
Neurons
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923022001666

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http://www.sciencedirect.com/science/article/pii/S0361923022001666

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