HBXIP induces anoikis resistance by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis and stabilize Prdx1 in breast cancer

HBXIP induces anoikis resistance by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis and stabilize Prdx1 in breast cancer

Abstract Anoikis resistance is an essential prerequisite for tumor metastasis, but the underlying molecular mechanisms remain unknown. Herein, we report that the oncoprotein hepatitis B X-interacting protein (HBXIP) is prominently upregulated in breast cancer cells following ECM detachment. Altering...

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Bibliographic Details
Main Authors: Xiaolei Zhou, Li Li, Xin Guo, Chunxiao Zhang, Yanyan Du, Tianming Li, Kaiqing Tong, Chongyue Zhu, Zijin Wang
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-021-00374-x

Internet

https://doi.org/10.1038/s41523-021-00374-x

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