Diesel Exhaust Particle (DEP)-induced glucose intolerance is driven by an intestinal innate immune response and NLRP3 activation in mice

Diesel Exhaust Particle (DEP)-induced glucose intolerance is driven by an intestinal innate immune response and NLRP3 activation in mice

Abstract Background We previously found that air pollution particles reaching the gastrointestinal tract elicit gut inflammation as shown by up-regulated gene expression of pro-inflammatory cytokines and monocyte/macrophage markers. This inflammatory response was associated with beta-cell dysfunctio...

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Bibliographic Details
Main Authors: Angela J. T. Bosch, Theresa V. Rohm, Shefaa AlAsfoor, Andy J. Y. Low, Zora Baumann, Neena Parayil, Faiza Noreen, Julien Roux, Daniel T. Meier, Claudia Cavelti-Weder
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Particle and Fibre Toxicology
Subjects:
Air pollution
Diesel exhaust particles
Gut exposure
Glucose metabolism
Metabolic disease
Gastrointestinal tract
Online Access:https://doi.org/10.1186/s12989-023-00536-8

Internet

https://doi.org/10.1186/s12989-023-00536-8

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