Could Extracellular Vesicles Contribute to Generation or Awakening of “Sleepy” Metastatic Niches?
Pre-metastatic niches provide favorable conditions for tumor cells to disseminate, home to and grow in otherwise unfamiliar and distal microenvironments. Tumor-derived extracellular vesicles are now recognized as carriers of key messengers secreted by primary tumors, signals that induce the formatio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.625221/full |
| _version_ | 1819179638217244672 |
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| author | Alberto Hernández-Barranco Laura Nogués Héctor Peinado |
| author_facet | Alberto Hernández-Barranco Laura Nogués Héctor Peinado |
| author_sort | Alberto Hernández-Barranco |
| collection | DOAJ |
| description | Pre-metastatic niches provide favorable conditions for tumor cells to disseminate, home to and grow in otherwise unfamiliar and distal microenvironments. Tumor-derived extracellular vesicles are now recognized as carriers of key messengers secreted by primary tumors, signals that induce the formation of pre-metastatic niches. Recent evidence suggests that tumor cells can disseminate from the very earliest stages of primary tumor development. However, once they reach distal sites, tumor cells can persist in a dormant state for long periods of time until their growth is reactivated and they produce metastatic lesions. In this new scenario, the question arises as to whether extracellular vesicles could influence the formation of these metastatic niches with dormant tumor cells? (here defined as “sleepy niches”). If so, what are the molecular mechanisms involved? In this perspective-review article, we discuss the possible influence of extracellular vesicles in early metastatic dissemination and whether they might play a role in tumor cell dormancy. In addition, we comment whether extracellular vesicle-mediated signals may be involved in tumor cell awakening, considering the possibility that extracellular vesicles might serve as biomarkers to detect early metastasis and/or minimal residual disease (MRD) monitoring. |
| first_indexed | 2024-12-22T22:01:37Z |
| format | Article |
| id | doaj.art-bb847e18051a44fbb3182d7e4d6590b7 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-22T22:01:37Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-bb847e18051a44fbb3182d7e4d6590b72022-12-21T18:11:07ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-03-01910.3389/fcell.2021.625221625221Could Extracellular Vesicles Contribute to Generation or Awakening of “Sleepy” Metastatic Niches?Alberto Hernández-BarrancoLaura NoguésHéctor PeinadoPre-metastatic niches provide favorable conditions for tumor cells to disseminate, home to and grow in otherwise unfamiliar and distal microenvironments. Tumor-derived extracellular vesicles are now recognized as carriers of key messengers secreted by primary tumors, signals that induce the formation of pre-metastatic niches. Recent evidence suggests that tumor cells can disseminate from the very earliest stages of primary tumor development. However, once they reach distal sites, tumor cells can persist in a dormant state for long periods of time until their growth is reactivated and they produce metastatic lesions. In this new scenario, the question arises as to whether extracellular vesicles could influence the formation of these metastatic niches with dormant tumor cells? (here defined as “sleepy niches”). If so, what are the molecular mechanisms involved? In this perspective-review article, we discuss the possible influence of extracellular vesicles in early metastatic dissemination and whether they might play a role in tumor cell dormancy. In addition, we comment whether extracellular vesicle-mediated signals may be involved in tumor cell awakening, considering the possibility that extracellular vesicles might serve as biomarkers to detect early metastasis and/or minimal residual disease (MRD) monitoring.https://www.frontiersin.org/articles/10.3389/fcell.2021.625221/fullextracellular vesicleexosomedormancymetastasisdisseminated tumor cells |
| spellingShingle | Alberto Hernández-Barranco Laura Nogués Héctor Peinado Could Extracellular Vesicles Contribute to Generation or Awakening of “Sleepy” Metastatic Niches? Frontiers in Cell and Developmental Biology extracellular vesicle exosome dormancy metastasis disseminated tumor cells |
| title | Could Extracellular Vesicles Contribute to Generation or Awakening of “Sleepy” Metastatic Niches? |
| title_full | Could Extracellular Vesicles Contribute to Generation or Awakening of “Sleepy” Metastatic Niches? |
| title_fullStr | Could Extracellular Vesicles Contribute to Generation or Awakening of “Sleepy” Metastatic Niches? |
| title_full_unstemmed | Could Extracellular Vesicles Contribute to Generation or Awakening of “Sleepy” Metastatic Niches? |
| title_short | Could Extracellular Vesicles Contribute to Generation or Awakening of “Sleepy” Metastatic Niches? |
| title_sort | could extracellular vesicles contribute to generation or awakening of sleepy metastatic niches |
| topic | extracellular vesicle exosome dormancy metastasis disseminated tumor cells |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.625221/full |
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