Fetal acidosis in a sheep model: can we perform a second day of protocol in order to reduce the numbers of animals needed?

Fetal acidosis in a sheep model: can we perform a second day of protocol in order to reduce the numbers of animals needed?

Objective: To determine if a model of acidosis caused by occlusion of the umbilical cord could be repeated in the same sheep in ethicaly order to reduce the number of animals needed. Method: To obtain fetal acidosis, 1 min of total umbilical cord occlusion (UCO) every 2.5 min was performed on fetal...

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Bibliographic Details
Main Authors: C. Pierre, L. Ghesquiere, J. De Jonckheere, E. Aubry, D. Sharma, P. Deruelle, L. Storme, V. Houfflin-Debarge, C. Garabedian
Format: Article
Language:English
Published: IMR Press 2020-02-01
Series:Clinical and Experimental Obstetrics & Gynecology
Subjects:
fetal sheep
animal experimentation
animal ethics
3r
umbilical cord occlusion
fetal acidosis
Online Access:https://www.imrpress.com/journal/CEOG/47/1/10.31083/j.ceog.2020.01.5120

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https://www.imrpress.com/journal/CEOG/47/1/10.31083/j.ceog.2020.01.5120

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