Characterization of Mono- and Bi-Transgenic Pig-Derived Epidermal Keratinocytes Expressing Human <i>FUT2</i> and <i>GLA</i> Genes—In Vitro Studies

Characterization of Mono- and Bi-Transgenic Pig-Derived Epidermal Keratinocytes Expressing Human <i>FUT2</i> and <i>GLA</i> Genes—In Vitro Studies

Pig-to-human xenotransplantation seems to be the response to the contemporary shortage of tissue/organ donors. Unfortunately, the phylogenetic distance between pig and human implies hyperacute xenograft rejection. In this study, we tested the hypothesis that combining expression of human α1,2-fucosy...

Full description

Bibliographic Details
Main Authors: Jerzy Wiater, Marcin Samiec, Kamil Wartalski, Zdzisław Smorąg, Jacek Jura, Ryszard Słomski, Maria Skrzyszowska, Marek Romek
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
genetically modified pig
epidermal keratinocyte
human α-1,2-fucosyltransferase
human α-galactosidase A
Galα1→3Gal epitope
Online Access:https://www.mdpi.com/1422-0067/22/18/9683

Internet

https://www.mdpi.com/1422-0067/22/18/9683

Similar Items