Evidence‐based rationale for low dose nivolumab in critically ill patients with sepsis‐induced immunosuppression

Abstract A substantial part of critically ill patients suffer from sepsis‐induced immunosuppression. Reversal of immunosuppression through PD‐1 checkpoint inhibition has been proposed as a treatment strategy to overcome immunosuppression in these patients. The PD‐1 inhibitor nivolumab, currently use...

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Bibliographic Details
Main Authors: Demy A. C. van denHaak, Leila‐Sophie Otten, Hans J. P. M. Koenen, Ruben L. Smeets, Berber Piet, Peter Pickkers, Matthijs Kox, Rob ter Heine
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.13503