Structural Analysis, Multi-Conformation Virtual Screening and Molecular Simulation to Identify Potential Inhibitors Targeting pS273R Proteases of African Swine Fever Virus

Structural Analysis, Multi-Conformation Virtual Screening and Molecular Simulation to Identify Potential Inhibitors Targeting pS273R Proteases of African Swine Fever Virus

The African Swine Fever virus (ASFV) causes an infectious viral disease in pigs of all ages. The development of antiviral drugs primarily aimed at inhibition of proteases required for the proteolysis of viral polyproteins. In this study, the conformation of the pS273R protease in physiological state...

Full description

Bibliographic Details
Main Authors: Gen Lu, Kang Ou, Yihan Zhang, Huan Zhang, Shouhua Feng, Zuofeng Yang, Guo Sun, Jinling Liu, Shu Wei, Shude Pan, Zeliang Chen
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
African swine fever
antiviral drugs
molecular dynamics simulation
multi-conformation virtual screening
Online Access:https://www.mdpi.com/1420-3049/28/2/570

Internet

https://www.mdpi.com/1420-3049/28/2/570

Similar Items