Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia

Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia

Abstract Background Current conventional chemotherapy for acute myeloid leukemia (AML) can achieve remission in over 70% of patients, but a majority of them will relapse within 5 years despite continued treatment. The relapse is postulated to be due to leukemia stem cells (LSCs), which are different...

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Bibliographic Details
Main Authors: Jianbiao Zhou, Chonglei Bi, Ying Qing Ching, Jing-Yuan Chooi, Xiao Lu, Jessie Yiying Quah, Sabrina Hui-Min Toh, Zit-Liang Chan, Tuan Zea Tan, Phyllis SY Chong, Wee-Joo Chng
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Journal of Hematology & Oncology
Subjects:
LIN28B
let-7 microRNA
Acute myeloid leukemia (AML)
Stem cell
Cancer metabolism
IGF2BP1
Online Access:http://link.springer.com/article/10.1186/s13045-017-0507-y

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http://link.springer.com/article/10.1186/s13045-017-0507-y

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