TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L

TRIM25 promotes Capicua degradation independently of ERK in the absence of ATXN1L

Abstract Background Aberrations in Capicua (CIC) have recently been implicated as a negative prognostic factor in a multitude of cancer types through the derepression of targets downstream of the mitogen-activated protein kinase (MAPK) signaling cascade, such as oncogenic E26 transformation-specific...

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Bibliographic Details
Main Authors: Derek Wong, Lisa Sogerer, Samantha S. Lee, Victor Wong, Amy Lum, Adrian B. Levine, Marco A. Marra, Stephen Yip
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Biology
Subjects:
Capicua
CIC
ATXN1L
MAPK
Ubiquitin
Proteasomal degradation
Online Access:http://link.springer.com/article/10.1186/s12915-020-00895-0

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http://link.springer.com/article/10.1186/s12915-020-00895-0

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