Characterization of Cationic Bolaamphiphile Vesicles for siRNA Delivery into Tumors and Brain

Characterization of Cationic Bolaamphiphile Vesicles for siRNA Delivery into Tumors and Brain

Small interfering RNAs (siRNAs) are potential therapeutic substances due to their gene silencing capability as exemplified by the recent approval by the US Food and Drug Administration (FDA) of the first siRNA therapeutic agent (patisiran). However, the delivery of naked siRNAs is challenging becaus...

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Bibliographic Details
Main Authors: Taejin Kim, Mathias Viard, Kirill A. Afonin, Kshitij Gupta, Mary Popov, Jacqueline Salotti, Peter F. Johnson, Charles Linder, Eliahu Heldman, Bruce A. Shapiro
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
Bolaamphiphiles
Vesicles
Delivery Systems
siRNA
Targeting
Blood Brain Barrier (BBB)
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120300883

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http://www.sciencedirect.com/science/article/pii/S2162253120300883

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