Soloxolone Methyl Reduces the Stimulatory Effect of Leptin on the Aggressive Phenotype of Murine Neuro2a Neuroblastoma Cells via the MAPK/ERK1/2 Pathway

Soloxolone Methyl Reduces the Stimulatory Effect of Leptin on the Aggressive Phenotype of Murine Neuro2a Neuroblastoma Cells via the MAPK/ERK1/2 Pathway

Despite the proven tumorigenic effect of leptin on epithelial-derived cancers, its impact on the aggressiveness of neural crest-derived cancers, notably neuroblastoma, remains largely unexplored. In our study, for the first time, transcriptome analysis of neuroblastoma tissue demonstrated that the l...

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Bibliographic Details
Main Authors: Kirill V. Odarenko, Oksana V. Salomatina, Ivan V. Chernikov, Nariman F. Salakhutdinov, Marina A. Zenkova, Andrey V. Markov
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Pharmaceuticals
Subjects:
leptin
neuroblastoma
adipokines
aggressiveness
triterpenoids
EMT
Online Access:https://www.mdpi.com/1424-8247/16/10/1369

Internet

https://www.mdpi.com/1424-8247/16/10/1369

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