Modeling the architecture of the regulatory system controlling methylenomycin production in Streptomyces coelicolor

Modeling the architecture of the regulatory system controlling methylenomycin production in Streptomyces coelicolor

Abstract Background The antibiotic methylenomycin A is produced naturally by Streptomyces coelicolor A3(2), a model organism for streptomycetes. This compound is of particular interest to synthetic biologists because all of the associated biosynthetic, regulatory and resistance genes are located on...

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Bibliographic Details
Main Authors: Jack E. Bowyer, Emmanuel LC. de los Santos, Kathryn M. Styles, Alex Fullwood, Christophe Corre, Declan G. Bates
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Journal of Biological Engineering
Subjects:
Synthetic biology
Antibiotics
Gene regulation
Methylenomycin
Mathematical modelling
Approximate Bayesian computation
Online Access:http://link.springer.com/article/10.1186/s13036-017-0071-6

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http://link.springer.com/article/10.1186/s13036-017-0071-6

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