HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness

HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness

High spliceosome activity is a dependency for cancer cells, making them more vulnerable to perturbation of the splicing machinery compared to normal cells. To identify splicing factors important for prostate cancer (PCa) fitness, we performed pooled shRNA screens in vitro and in vivo. Our screens id...

Full description

Bibliographic Details
Main Authors: Jessica SY Ho, Federico Di Tullio, Megan Schwarz, Diana Low, Danny Incarnato, Florence Gay, Tommaso Tabaglio, JingXian Zhang, Heike Wollmann, Leilei Chen, Omer An, Tim Hon Man Chan, Alexander Hall Hickman, Simin Zheng, Vladimir Roudko, Sujun Chen, Alcida Karz, Musaddeque Ahmed, Housheng Hansen He, Benjamin D Greenbaum, Salvatore Oliviero, Michela Serresi, Gaetano Gargiulo, Karen M Mann, Eva Hernando, David Mulholland, Ivan Marazzi, Dave Keng Boon Wee, Ernesto Guccione
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
splicing
antisense oligonucleotides
circular RNA
Online Access:https://elifesciences.org/articles/59654

Internet

https://elifesciences.org/articles/59654

Similar Items