Human amniotic membrane modulates Wnt/β-catenin and NF-κβ signaling pathways in articular chondrocytes in vitro

Human amniotic membrane modulates Wnt/β-catenin and NF-κβ signaling pathways in articular chondrocytes in vitro

Objective: Inflammation, catabolism, and hypertrophy in chondrocytes play a central role in osteoarthritis (OA). The Wnt/β-catenin and NF-κβ pathways contribute to these degradative processes. This in vitro study evaluates the inhibitory effect of a novel therapeutic, micronized dehydrated human amn...

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Bibliographic Details
Main Authors: Connie Chung, Michelle Massee, Thomas J. Koob
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Osteoarthritis and Cartilage Open
Subjects:
Wnt
NF-κβ
Osteoarthritis
Chondrocyte
Amniotic membrane
ECM catabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2665913121000741

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http://www.sciencedirect.com/science/article/pii/S2665913121000741

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