Blockade of the lncRNA-DOT1L-LAMP5 axis enhances autophagy and promotes degradation of MLL fusion proteins

Blockade of the lncRNA-DOT1L-LAMP5 axis enhances autophagy and promotes degradation of MLL fusion proteins

Abstract Background Mixed-lineage leukemia (MLL) fusion gene caused by chromosomal rearrangement is a dominant oncogenic driver in leukemia. Due to having diverse MLL rearrangements and complex characteristics, MLL leukemia treated by currently available strategies is frequently associated with a po...

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Bibliographic Details
Main Authors: Tian-Qi Chen, Heng-Jing Huang, Shun-Xin Zhu, Xiao-Tong Chen, Ke-Jia Pu, Dan Wang, Yan An, Jun-Yi Lian, Yu-Meng Sun, Yue-Qin Chen, Wen-Tao Wang
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Experimental Hematology & Oncology
Subjects:
lncRNA
LAMP5-AS1
DOT1L
LAMP5
Autophagy
MLL leukemia
Online Access:https://doi.org/10.1186/s40164-024-00488-5

Internet

https://doi.org/10.1186/s40164-024-00488-5

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