Identification of the ubiquitin–proteasome pathway domain by hyperparameter optimization based on a 2D convolutional neural network

Identification of the ubiquitin–proteasome pathway domain by hyperparameter optimization based on a 2D convolutional neural network

The major mechanism of proteolysis in the cytosol and nucleus is the ubiquitin–proteasome pathway (UPP). The highly controlled UPP has an effect on a wide range of cellular processes and substrates, and flaws in the system can lead to the pathogenesis of a number of serious human diseases. Knowledge...

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Bibliographic Details
Main Authors: Rahu Sikander, Muhammad Arif, Ali Ghulam, Apilak Worachartcheewan, Maha A. Thafar, Shabana Habib
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Genetics
Subjects:
ubiquitin-proteasome pathway
DDE
protein sequence prediction
CNN
2D-CNN
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.851688/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.851688/full

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