Exposure of human immune cells, to the antiretrovirals efavirenz and lopinavir, leads to lower glucose uptake and altered bioenergetic cell profiles through interactions with SLC2A1

Exposure of human immune cells, to the antiretrovirals efavirenz and lopinavir, leads to lower glucose uptake and altered bioenergetic cell profiles through interactions with SLC2A1

SLC2A1 mediates glucose cellular uptake; key to appropriate immune function. Our previous work has shown efavirenz and lopinavir exposure inhibits T cell and macrophage responses, to known agonists, likely via interactions with glucose transporters. Using human cell lines as a model, we assessed glu...

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Bibliographic Details
Main Authors: Bethany J. Heaton, Rebecca L. Jensen, James Line, Christopher A.W. David, Danielle E. Brain, Amy E. Chadwick, Neill J. Liptrott
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Antiretroviral
Immune response
HIV
Membrane transporter
Glucose
Bioenergetics
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222003882

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http://www.sciencedirect.com/science/article/pii/S0753332222003882

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