Angiotensin Type-1 Receptor Inhibition Reduces NLRP3 Inflammasome Upregulation Induced by Aging and Neurodegeneration in the <i>Substantia Nigra</i> of Male Rodents and Primary Mesencephalic Cultures

Angiotensin Type-1 Receptor Inhibition Reduces NLRP3 Inflammasome Upregulation Induced by Aging and Neurodegeneration in the <i>Substantia Nigra</i> of Male Rodents and Primary Mesencephalic Cultures

The tissue renin–angiotensin system (RAS) has been shown to be involved in prooxidative and proinflammatory changes observed in aging and aging-related diseases such as dopaminergic degeneration in Parkinson’s disease (PD). We studied the activation of the NLRP3 inflammasome in the <i>substant...

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Bibliographic Details
Main Authors: Aloia Quijano, Carmen Diaz-Ruiz, Andrea Lopez-Lopez, Begoña Villar-Cheda, Ana Muñoz, Ana I. Rodriguez-Perez, Jose L. Labandeira-Garcia
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Antioxidants
Subjects:
aged
dopamine
inflammation
inflammaging
neuroinflammation
oxidative stress
Online Access:https://www.mdpi.com/2076-3921/11/2/329

Internet

https://www.mdpi.com/2076-3921/11/2/329

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