Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21

Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21

Highly concentrated trehalose induces beneficial senescence-like state in fibroblasts and accelerates the proliferation of keratinocytes and angiogenesis to promote optimal wound repair, demonstrating its therapeutic potential in modulating fibroblast functions.

Bibliographic Details
Main Authors: Jun Muto, Shinji Fukuda, Kenji Watanabe, Xiuju Dai, Teruko Tsuda, Takeshi Kiyoi, Kenji Kameda, Ryosuke Kawakami, Hideki Mori, Ken Shiraishi, Masamoto Murakami, Takeshi Imamura, Shigeki Higashiyama, Yasuhiro Fujisawa, Yoichi Mizukami, Koji Sayama
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-04408-3

Internet

https://doi.org/10.1038/s42003-022-04408-3

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