Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies

Design of a Proteolytically Stable Sodium-Calcium Exchanger 1 Activator Peptide for In Vivo Studies

The cardiac sodium–calcium exchanger (NCX1) is important for normal Na+- and Ca2+-homeostasis and cardiomyocyte relaxation and contraction. It has been suggested that NCX1 activity is reduced by phosphorylated phospholemman (pSer68-PLM); however its direct interaction with PLM is debated. Disruption...

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Bibliographic Details
Main Authors: Pimthanya Wanichawan, Jonas Skogestad, Marianne Lunde, Thea Parsberg Støle, Maria Stensland, Tuula A. Nyman, Ivar Sjaastad, Ole M. Sejersted, Jan Magnus Aronsen, Cathrine Rein Carlson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
PLM
NCX1
disruptor peptide
NKA
cardiac
brain
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.638646/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.638646/full

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