miR‐133a Replacement Attenuates Thoracic Aortic Aneurysm in Mice

miR‐133a Replacement Attenuates Thoracic Aortic Aneurysm in Mice

Background Thoracic aortic aneurysms (TAAs) occur because of abnormal remodeling of aortic extracellular matrix and are accompanied by the emergence of proteolytically active myofibroblasts. The microRNA miR‐133a regulates cellular phenotypes and is reduced in clinical TAA specimens. This study test...

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Bibliographic Details
Main Authors: Adam W. Akerman, Elizabeth N. Collins, Andrew R. Peterson, Lauren B. Collins, Jessica K. Harrison, Amari DeVaughn, Jaleel M. Townsend, Rebecca L. Vanbuskirk, Jessica Riopedre‐Maqueira, Ailet Reyes, Joyce E. Oh, Charles M. Raybuck, Jeffrey A. Jones, John S. Ikonomidis
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
fibroblast
furin
miR‐133a
myofibroblast
thoracic aortic aneurysm
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.019862

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.120.019862

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