Rbf/E2F1 control growth and endoreplication via steroid-independent Ecdysone Receptor signalling in Drosophila prostate-like secondary cells.

Rbf/E2F1 control growth and endoreplication via steroid-independent Ecdysone Receptor signalling in Drosophila prostate-like secondary cells.

In prostate cancer, loss of the tumour suppressor gene, Retinoblastoma (Rb), and consequent activation of transcription factor E2F1 typically occurs at a late-stage of tumour progression. It appears to regulate a switch to an androgen-independent form of cancer, castration-resistant prostate cancer...

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Bibliographic Details
Main Authors: Aashika Sekar, Aaron Leiblich, S Mark Wainwright, Cláudia C Mendes, Dhruv Sarma, Josephine E E U Hellberg, Carina Gandy, Deborah C I Goberdhan, Freddie C Hamdy, Clive Wilson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-06-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010815&type=printable

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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010815&type=printable

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