New Amino Naphthoquinone Derivatives as Anti-<i>Trypanosoma cruzi</i> Agents Targeting Trypanothione Reductase

New Amino Naphthoquinone Derivatives as Anti-<i>Trypanosoma cruzi</i> Agents Targeting Trypanothione Reductase

To develop novel chemotherapeutic alternatives for the treatment of Chagas disease, in this study, a set of new amino naphthoquinone derivatives were synthesised and evaluated in vitro on the epimastigote and trypomastigote forms of <i>Trypanosoma cruzi</i> strains (NINOA and INC-5) and...

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Bibliographic Details
Main Authors: Christian Espinosa-Bustos, Mariana Ortiz Pérez, Alonzo Gonzalez-Gonzalez, Ana María Zarate, Gildardo Rivera, Javier A. Belmont-Díaz, Emma Saavedra, Mauricio A. Cuellar, Karina Vázquez, Cristian O. Salas
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Pharmaceutics
Subjects:
<i>Trypanosoma cruzi</i>
amino naphthoquinones
trypomastigote
epimastigote
trypanothione reductase
docking studies
Online Access:https://www.mdpi.com/1999-4923/14/6/1121

Internet

https://www.mdpi.com/1999-4923/14/6/1121

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