An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H-<i>Ras</i>-Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target

An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H-<i>Ras</i>-Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target

Signal transducer and activator of transcription 3 (STAT3) is a point of convergence for numerous oncogenic signals that are often constitutively activated in many cancerous or transformed cells and some stromal cells in the tumor microenvironment. Persistent STAT3 activation in malignant cells stim...

Full description

Bibliographic Details
Main Authors: Sung-Jun Hong, Jin-Tae Kim, Su-Jung Kim, Nam-Chul Cho, Kyeojin Kim, Seungbeom Lee, Young-Ger Suh, Kyung-Cho Cho, Kwang Pyo Kim, Young-Joon Surh
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Biomedicines
Subjects:
STAT3
deguelin
SH48
α,β-unsaturated carbonyl group
MCF10A-<i>ras</i> cells
autophagy
Online Access:https://www.mdpi.com/2227-9059/8/10/407

Internet

https://www.mdpi.com/2227-9059/8/10/407

Similar Items