Amyloid Precursor Protein A713T Mutation in Calabrian Patients with Alzheimer’s Disease: A Population Genomics Approach to Estimate Inheritance from a Common Ancestor

Amyloid Precursor Protein A713T Mutation in Calabrian Patients with Alzheimer’s Disease: A Population Genomics Approach to Estimate Inheritance from a Common Ancestor

Mutation A713T in the amyloid precursor protein (APP) has been linked to cases of Alzheimer’s disease (AD), cerebral amyloid angiopathy (CAA) and cerebrovascular disease. Despite its rarity, it has been observed in several families from the same geographical area, in the Calabria region in Southern...

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Bibliographic Details
Main Authors: Paolo Abondio, Stefania Sarno, Cristina Giuliani, Valentina Laganà, Raffaele Maletta, Livia Bernardi, Francesco Bruno, Rosanna Colao, Gianfranco Puccio, Francesca Frangipane, Barbara Borroni, Christine Van Broeckhoven, Donata Luiselli, Amalia Bruni
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biomedicines
Subjects:
APP
amyloid
Alzheimer’s disease
neurodegeneration
population genomics
common ancestor
Online Access:https://www.mdpi.com/2227-9059/10/1/20

Internet

https://www.mdpi.com/2227-9059/10/1/20

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