Development of an Effective Nontoxigenic Clostridioides difficile–Based Oral Vaccine against C. difficile Infection

Development of an Effective Nontoxigenic Clostridioides difficile–Based Oral Vaccine against C. difficile Infection

ABSTRACT The symptoms of Clostridioides difficile infection (CDI) are largely attributed to two C. difficile toxins, TcdA and TcdB. Significant efforts have been devoted to developing vaccines targeting both toxins through parenteral immunization routes. Recently, we generated a novel chimeric prote...

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Bibliographic Details
Main Authors: Shaohui Wang, Duolong Zhu, Xingmin Sun
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:Microbiology Spectrum
Subjects:
nontoxigenic Clostridioides difficile
Clostridioides difficile infection
chimeric protein
vaccine
spore
oral immunization
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00263-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.00263-22

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